SBGrid Community News

SBGrid Community News

SBGrid

How microbes make designer antibiotics

SBGrid member Yvain Nicolet from IBS Grenoble explores how bacteria make antibiotics.

May 29

Many colorful (pink, black, white, orange, brown) antibiotic capsules and tablets piled together

May 29

SBGrid

The Final Phase

George Phillips, at Rice University, plans to continue tinkering with the “phase problem” once officially retired.

May 29

May 29

SBGrid

Exploring MIF inhibition in Acute Myeloid Leukemia

SBGrid member Elias Lolis examines the immune protein MIF with an allosteric inhibitor, which can halt leukemia cell growth.

May 29

Small molecular inhibitor (blue — 2:00 and 7:00) bound to MIF (purple). CC BY SBGRID. PDB 8SON.

May 29

SBGrid

Working to reduce hospital-acquired infections

SBGrid member Graeme Conn provides a compelling review of the antibiotic resistant causing protein MexXY.

Apr 28

A colorful array of antibiotic tablets in partially used packets.

Apr 28

SBGrid

Unlocking the Secrets of Anesthesia: A Closer Look at the THIK1 K2P Channel

SBGrid member Paul Riegelhaupt reveals how anesthetics shut down brain activity by closing the THIK1 potassium channel.

Apr 28

THIK1 Channel. Residues highlighted in pink form the central pore gate. CC BY SBGRID.

Apr 28

SBGrid

Mind and Muscle

Ryan Hibbs at the University of California, San Diego, studies the structure and function of the ion channels to figure out how they…

Mar 28

Head shot of Professor Ryan Hibbs smiling with background blurred.

Mar 28

SBGrid

Externalization of phospholipids by dual functioning proteins in hearing

SBGrid member Jeffrey Holt examines how TMC1 and TMC2 function as essential lipid scramblases.

Mar 28

Externalization of phospholipids by dual functioning proteins in hearing

Mar 28

SBGrid

Unlocking key steps of H. pylori growth to design better treatments for ulcers

SBGrid member Craig. Smith solved the first structure of H. pylori DHODH, finding essential motifs and key residues.

Mar 28

Dihydroorotate dehydrogenase from H. pylori bound. PDB:6BS8. CC BY SBGRID

Mar 28

SBGrid

A potential target for mycobacteria

SBGrid member Eilika Weber-Ban study of transcription factor PafBC in mycobacteria reveals it is activated by single-stranded DNA (ssDNA)

Feb 27

RNA Polymerase (green) — PafBC (blue) complex bound to DNA (orange)

Feb 27

SBGrid

Looking at the bacterial artillery

SBGrid member Matteo Dal Peraro shows a high resolution structure of the machine bacteria use to attack our cells.

Feb 27

Cryo-EM structure of aerolysin assembly in a lipid membrane with each monomer labeled in a different color (PDB 9FM6). CC BY SBGRID.

Feb 27

SBGrid Community News

News and highlights about scientists and software developers in the SBGrid community. The SBGrid Communities Project demonstrates how structural biology and preclinical science connect to medicine, a collaboration between SBGrid PI Piotr Sliz Jamaine Davis of Belmont University

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Editors

SBGrid

Harvard-based consortium curating structural biology (CryoEM Crystallography NMR Tomography) software and supporting education & access to scientific resources.

Scott Barclay

Michelle Ottaviano

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