OpenCog Hyperon: Revolutionizing Biomedical Research for Longevity with the Rejuve.Bio FlyBase Integration

SingularityNET
SingularityNET
Published in
6 min readMar 21, 2024

Dear Singularitarians,

The development of advanced Artificial Intelligence systems capable of carrying out a wide range of tasks and transferring knowledge across contexts has been a critical missing component in the field of AI. Nonetheless, we have seen significant improvements in AI in recent years.

The OpenCog Hyperon framework aims to bridge this gap by providing an integrative cognitive architecture and AI system design with the breadth and complexity required to achieve Artificial General Intelligence (AGI) at the human level and beyond.

We see this as having the potential to significantly impact various fields, including life sciences, education, environmental science, finance, economics, robotics, urban planning, and smart cities, among others.”

The development of OpenCog Hyperon in partnership with Rejuve.Bio, a biotech company specializing in longevity research, has the potential to significantly scale its longevity research programs and transform pharmaceutical development.

In this article, we look at some of the most recent developments in OpenCog Hyperon, emphasizing the importance of integrating the FlyBase to advance Rejuve.Bio’s research and accelerate drug discovery.

Recent Updates to OpenCog Hyperon

There have been significant advancements in the translation of OpenCog Classic algorithms to the Meta Type Talk (MeTTa), Hyperon’s purpose-built language for cognitive computations which provides an interoperability and communication layer to the architecture.

The emphasis has been on adapting pattern mining and Probabilistic Logic Networks (PLN) algorithms to MeTTa. By leveraging MeTTa’s capabilities, these initiatives are aimed at improving OpenCog Hyperon’s functionality.

By design, OpenCog supposes implementing a variety of cognitive algorithms on top of its core components to perform knowledge-based reasoning and problem-solving in a synergistic manner. Of special importance is PLN, a logic designed to emulate human-like common sense reasoning. This logic excels at dealing with uncertainty, both empirical and abstract knowledge, and the relationships between them.

The porting of Pattern Mining to MeTTa is another important development for OpenCog Hyperon. Pattern Mining enables the extraction of meaningful patterns and relationships from large datasets. Integrating the Distributed Atomspace’s (DAS) Pattern Matching queries into MeTTa allows OpenCog Hyperon to discover and utilize patterns within a variety of contexts, including the analysis of longevity research questions using Rejuve’s cross-organism datasets.

These most recent updates represent the ongoing work to improve OpenCog Hyperon’s capabilities and showcase our commitment to achieving Beneficial General Intelligence (BGI).

One of the initial use cases for OpenCog Hyperon is in the field of Bio-AI, specifically for generating hypotheses in longevity genomics research. This practical application can be seen in the longevity studies conducted by Rejuve.Bio.

Integrating the FlyBase into OpenCog Hyperon

The longevity studies at Rejuve.Bio heavily rely on having the Flybase datasets uploaded to our BioAtomSpace. The FlyBase is a vast database for all types of genetic research on the fruit fly Drosophila melanogaster, a population of fruit flies that have been selectively bred for long lifespans.

FlyBase has been imported into OpenCog Hyperon, giving Rejuve.Bio access to a massive database of 330 million atoms in the Atomspace. However, this is only a subset used for the current testing version.

This integration enables effective data analysis and hypothesis generation by enabling researchers to run AI algorithms on the FlyBase data, including graph traversal and pattern matching.

This will substantially accelerate the rate of discovery along the drug and development pipeline, allowing Rejuve.Bio to develop better biomarkers and new longevity therapeutics.

How AI will help scale Rejuve.Bio’s operations and advance longevity research

To create scientifically-proven, AI-driven solutions, Rejuve.Bio combines state-of-the-art AI technology — OpenCog Hyperon — with extensive biomedical knowledge and genetic insights from long-lived Methuselah Flies and human data sets.

OpenCog Hyperon is integrating data from various sources, including the flies and Flybase, as well as human datasets and other longevity animal models, into the BioAtomspace. This comprehensive dataset enables the BioAtomspace to identify common genetic pathways and targets and helps advance Rejuve.Bio’s mission to revolutionize the field of longevity treatments and extend human health span to new levels.

Rejuve.Bio is embarking on a crowdsourcing mission to deepen our understanding of human longevity.

Users of the Rejuve.AI Longevity App will have the option to voluntarily add their data to the BioAtomspace. These users will be instrumental in advancing our research efforts and identifying potential longevity breakthroughs by voluntarily sharing their data.

The BioAtomspace will produce inferences, hypotheses, and insights that direct Rejuve.Bio’s research endeavors using data from flies, flybase, and human sources. Fruit flies, their in-house longevity animal model, provide an invaluable point of comparison, and the addition of human data enables us to investigate the complexities of human biology and aging.

Rejuve.Bio’s leveraging of OpenCog Hyperon, fueled by the incorporation of FlyBase, offers both projects several benefits and opportunities.

  • The research team will be able to create the foundations of new longevity treatments faster by utilizing AI algorithms and testing substances on their fruit flies;
  • By leveraging OpenCog Hyperon, Rejuve.Bio gains access to a wealth of biomedical resources. Biomedical research is an ideal use case for showcasing Opencog Hyperon’s capabilities because of the vast amount of existing data and curated machine-readable knowledge that’s publicly available, as well as the many classes of problems requiring complex multistep reasoning that have existing solutions available (for example, finding causal hypotheses connecting mutations to phenotypes.)
  • The use of neural-symbolic AI in OpenCog Hyperon enables researchers to navigate more complicated decision-making processes, cut their learning curve, recognize new patterns, and find new avenues and pathways to achieving their end goal of creating innovative longevity therapeutics.

This effective fusion of symbolic reasoning and foundational transformer models is poised to increase the speed at which new, improved longevity therapeutics are created.

These developments of OpenCog Hyperon represent a landmark step forward in the pursuit of early-stage AGI-driven therapeutics. The integration of FlyBase, facilitated by OpenCog Hyperon, is set to transform the biomedical industry.

Join the Rejuve.bio Crowdsale

Recently, Rejuve.Bio announced the launch of their Crowd Fund Raise on the NetCapital platform. This is an unprecedented opportunity for those who want to position themselves at the forefront of the Artificial General Intelligence revolution. Rejuve.Bio is set to redefine the future of technology and reshape the world as we know it!

To learn more, visit the Rejuve.bio website or explore the crowdfund on the NetCapital platform.

Disclaimer: Content published by SingularityNET is meant for informational purposes only and is not intended to serve as a recommendation to buy or sell any security in a self-directed account and is not an offer or sale of a security. Any investment is not directly managed by SingularityNET or Rejuve.Bio. All investments involve risk, and the past performance of a security or financial product does not guarantee future results or returns. Potential investors should seek professional advice and carefully review all documentation before making any investment decisions.

About SingularityNET

SingularityNET is a decentralized AI Platform and Marketplace for Artificial Intelligence (AI) services. Our mission is the creation of a decentralized, democratic, inclusive, and beneficial Artificial General Intelligence (AGI), democratizing access to AI and AGI technologies through:

  • Our Platform, where anyone can develop, share, and monetize AI algorithms, models, and data.
  • OpenCog Hyperon, our premier neural-symbolic AGI Framework, will be a core service for the next wave of AI innovation.
  • Our Ecosystem, developing advanced AI solutions across market verticals to revolutionize industries.

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SingularityNET
SingularityNET

The world's first decentralized Artificial Intelligence (AI) network