Lupus Triggers

Lupus Triggers: 5 Common Medications That Cause Lupus

Fortunately, this form of lupus is less severe and more easily resolved than SLE — if you know which medicines caused it.

Stephanie Jyet Quan Loo
The Microscope
Published in
7 min readJan 12, 2024

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Image adapted from Freepik.com

Between 1943 and 1945, Captain Byron J. Hoffman, a U.S. Army physician, confronted a medical conundrum when a young recruit fell victim to a stubborn infection. Months later, the recruit, initially battling the disease, grappled with rashes that surfaced on his hands and, peculiarly, expanded to the face when touched by sunlight.

Since the infection, a symphony of medications played its tune over the months. Among them was sulfadiazine, a formidable antimicrobial drug. Yet, some symptoms persist, if not worsened. Hoffman, acting as both investigator and healer, began to suspect sulfadiazine’s role in drug sensitivity.

Indeed, with each dose of sulfadiazine, the recruit exhibited telltale signs — fatigue, muscle aches, headaches, and a persistent daze. These symptoms resemble systemic lupus erythematosus (SLE) — the most common and severe form of lupus.

As Hoffman strategically moved to withdraw sulfadiazine from the line of treatments and the young soldier treated for lupus, the symptoms faded, including the enigmatic skin rashes…

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