Twitter Explainer: Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate CancerBrendan Reardon·FollowPublished invanallenlab·1 min read·Apr 4, 2018--ShareFigure 1a: Schematic overview of paired (pre- and post-treatment) tumor biopsy collection in the context of next-generation ADT, abiraterone, and enzalutamide, followed by whole-exome sequencing and computational analysis to investigate clinical resistance mechanisms.