Figure 4a: Most genomic alterations are enriched in metastatic disease. Alteration percentages in metastatic samples (n = 333) are shown on the x axis, and those in primary samples (n = 680) are shown on the y axis. The significance of enrichment (two-sided Fisher’s test q value or weighted permutation test) is shown by the size of the dots. Genes in bold have a significant enrichment of mutations using Fisher’s test and weighted permutation test correcting for mutation burden.
