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What Happens to Your Brain When Someone Breaks Your Heart

After you’ve been dumped, how do you pick up the pieces and find happiness again? Science offers insights.

Kathleen Murphy
Wise & Well
Published in
6 min readFeb 12, 2025

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Image by Freepik

When my husband packed up and left for good, I went through drug withdrawal.

I wasn’t addicted to alcohol, marijuana, cocaine, or any other intoxicant. But I experienced the same common symptoms: crying spells, lethargy, anxiety, irritability, insomnia, and loss of appetite.

I also relapsed like an addict. Long after my husband moved on, any random signal — a restaurant, a melody, a joke, a TV show, anything really — could send me into a fresh spiral of panic, anxiety, and tears.

I’d compulsively replay cheesy breakup songs. I’d retell my victim story again and again to anyone with ears. I’d binge-watch true crime shows and root for the jilted lovers who followed through on their revenge fantasies.

If it sounds like I was a little bit nuts, you’re right. But what I didn’t know at the time was that my brain — overdosing on some brain chemicals and starving for others — was doing exactly what it was designed to do.

The jilted brain

At some point in our lives, nearly all of us experience the anguish of rejection…

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Wise & Well
Wise & Well

Published in Wise & Well

Science-backed insights into health, wellness and wisdom, to help you make tomorrow a little better than today.

Kathleen Murphy
Kathleen Murphy

Written by Kathleen Murphy

Health journalist & essayist offering insights into physical & emotional wellness and successful aging. Subscribe: https://kathleenamurphy.medium.com/subscribe

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