How to select a high pressure homogenizer？
High-pressure homogenizers are essential tools in various industries, ensuring efficient processing and product quality. Selecting the ideal high-pressure homogenizer involves several crucial considerations to achieve optimal results. Here’s a guide on how to make the right choice:
1. Choosing the High-Pressure Generator:
When it comes to high-pressure generators, a cylinder with an intensifier is generally preferred over a direct-drive mechanism. Higher pressure levels offer advantages like reduced frequency, fewer pressure fluctuations, improved product quality, and enhanced equipment durability. For instance, Genizer’s laboratory high-pressure homogenizer, Nanogenizer3, operates at 30,000 psi with minimal fluctuations of less than 10 Hz, as opposed to the 60 Hz typical of regular homogenizers.
NanoGenizer High Pressure Homogenizer
High-Pressure Piston Materials:
High-pressure pistons are available in ceramics, tungsten carbide, and hardened stainless steel. Ceramics are the highest quality but costly, while hardened stainless steel offers a more affordable option. Quality and durability align with cost, making ceramics the top choice, followed by hard tungsten alloy, and finally, hardened stainless steel.
ceramic piston
2. Selecting Homogenization Components:
As a core component of homogenizers, homogenization chambers play a decisive role in achieving optimum results for the process. Different inner constructions of homogenization chambers lead to different results and applications.
Homogenization chamber performance comparison
When selecting a suitable homogenizer, the purchaser must consider both performance and cost. In general, the cost of the first-generation homogenization chamber is more economical, but its performance in the homogenization process is not as good as the second generation’s. The second-generation homogenization chamber produces a superior product, but when processing materials with high concentration and viscosity, it is more likely to block than first-generation machines, and its cost is higher as well. The interaction chamber with a cooling system, developed by Genizer, can be used for thermally unstable biological and pharmaceutical products.
3. Maximum Homogenizing Pressure:
In general, higher homogenizing pressure leads to better quality. This is because the particle size will be much smaller and more uniform if the homogenizer’s pressure is higher, which means processors produce the nanomaterial more efficiently. Higher homogenizing pressure also allows more kinds of samples to be processed. For example, emulsions usually require a homogenizing pressure of 20,000 psi to achieve a particle size of 100 nm, while suspensions usually require at least 45,000 psi to reach nanoscale.
It should also be noted that high temperature will affect the results of the homogenization process. The higher the pressure is, the higher the temperature will be. Because of this, 30,000 psi is the maximum pressure for high pressure homogenization without a cooling system. Due to the high temperature, the homogenization effect of more than 30,000 psi does not increase with pressure. The development of the ultra-high pressure diamond interaction chamber with a cooling system can effectively reduce the content of large particles and solve the problem of emulsion stability caused by high temperature. Therefore, machines equipped with this type of chamber can achieve pressures up to 60,000 psi.
4. Ensuring Product Uniformity:
Achieving a uniform particle size distribution is crucial in production processes. Wide distributions, spanning from nanometers to microns, are often unacceptable, especially in pharmaceutical emulsions. Regulatory bodies like the US Pharmacopeia (USP) have specific requirements for particle size distribution. Interaction chambers typically produce more uniform distributions compared to impact valve homogenizers.
By considering these factors, you can confidently select the right high-pressure homogenizer, like the Genizer High Pressure Homogenizer, to meet your specific processing needs and quality standards.
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