Working with only few fixed grid configurations makes it easy to miss problems while you’re working. Either the developer will find them during implementation — necessitating a lot of annoying back-and-forth — or the broken layouts will end up in your final product.
This works fine for print. The designer knows that their publication is going to use, say, the A4 paper size. But what happens in digital, when you need to simulate a different device size? Changing the artboard dimensions means that the grid either is either too big or too small:
75% of interface designers primarily use Photoshop, Illustrator, or Sketch. Each of these tools was created around the metaphor of the page, not the screen. Unsurprisingly, the methods for working with grids in these tools are also based on the print tradition. For digital product designers, this leads to some big pain points in everyday use.