Every pharmaceutical and medical device company in the world is trying to grow their markets and better meet the needs of medically underserved populations. While most business leaders understand these opportunities, realizing this potential is a different story. To do so, companies must work in new ways, develop deep external partnerships, and grapple with some of the most complex, multi-faceted challenges we face as a global community. Fortunately, this complexity has not deterred some innovative companies who are actively working to create shared value. Here, we highlight the work of these shared value leaders — pharmaceutical, medical device, and complementary companies working to improve business competitiveness by addressing health challenges. We will explore burgeoning efforts and long-standing initiatives, learn about work in communities from the southern U.S. to South Africa to China, and we will hear directly from leading shared value practitioners about their successes, struggles, and hard-won lessons learned.