Emerging Concerns of Elevated Uric Acid on Obesity, Diabetes, Heart Disease, Impotence, & Dementia
Hyperuricemia is increasing globally and affecting millions of Americans. Why does the body create excessive uric acid, and how can we lower its impact to prevent associated disorders?
Understanding the adverse effects of waste products, which we call cellular debris, on the brain has been a strong research interest for me. Cellular debris mainly comprises damaged organelles, misfolded proteins, and some degraded neurotransmitters.
However, during my research into metabolism in the 1990s, I also encountered waste products the cells, tissues, and organs create due to the metabolic processes. In the early 2000s, several studies indicated that elevated uric acid was a predictor of cardiovascular mortality.
For example, I came across an eye-opening investigation paper published in JAMA in 2004 titled Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-aged Men. These researchers concluded that serum uric acid levels are a strong predictor of cardiovascular disease mortality in healthy middle-aged men, independent of variables…
