Redux is the React framework that other flux frameworks recommend you use. It went 1.0.0 when I started writing this (and is at the time of publishing past 3.0.0!) and it’s still early days as to how to use it.
I just migrated off RequireJS to Webpack, having last week moved from ES5 to ES6. One more migration to go and we’re running a totally 2015 compliant webapp (React+Backbone -> something Flux-ish)!