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Meta Multiomics
Deciphering the Language of Life
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Optimizing Bioreactor Design using Math
Optimizing Bioreactor Design using Math
People often ask how can math truly impact fields like biology. In genomics, where complex biological systems are modeled, math doesn’t…
Freedom Preetham
Oct 16
Why NK vs. CAR-T Might Be a Short-Lived Debate
Why NK vs. CAR-T Might Be a Short-Lived Debate
Rethinking the Future of Cell Therapy
Freedom Preetham
Oct 9
Redefining Cellular Insights: Universal Embeddings and Beyond
Redefining Cellular Insights: Universal Embeddings and Beyond
I came across this paper on bioarxiv titled Universal Cell Embedding (UCE), and it provides a novel and intriguing solution to a critical…
Freedom Preetham
Oct 8
Why In Silico Genomic Models Outperform Wet Labs
Why In Silico Genomic Models Outperform Wet Labs
The Future of Biological Research
Freedom Preetham
Oct 6
Simulating the Gene Regulatory Network is the Most Important Step of Constructing an AI Virtual…
Simulating the Gene Regulatory Network is the Most Important Step of Constructing an AI Virtual…
As I struggled through my research to simulate a biological cell in its entirety, I realized early on that simulating the Gene Regulatory…
Freedom Preetham
Sep 25
Fourier Neural Operators in Gene Transcription
Fourier Neural Operators in Gene Transcription
Solving Higher Frequency and Non-Periodic Boundary Challenges
Freedom Preetham
Sep 24
Biologically-Informed Downsampling of Genomic Sequences: Mathematical Methods in Genomics
Biologically-Informed Downsampling of Genomic Sequences: Mathematical Methods in Genomics
As the complexity and scale of genomic data continue to grow, I find that there is a pressing need for advanced computational techniques…
Freedom Preetham
Aug 21
The Decade of Artificial Biological Intelligence
The Decade of Artificial Biological Intelligence
I believe the next decade will be defined by an unprecedented shift toward understanding and harnessing biological intelligence. At the…
Freedom Preetham
Aug 18
Exploring the Challenges of Protein-Ligand Binding Predictions in AI Through Leash Bio’s BELKA…
Exploring the Challenges of Protein-Ligand Binding Predictions in AI Through Leash Bio’s BELKA…
I’ve been following developments in the field of protein-binding affinity for some time (even though my focus is Genomics), driven by a…
Freedom Preetham
Aug 15
Why Biology Needs Physics and Mathematics
Why Biology Needs Physics and Mathematics
The idea that biology is fundamentally separate from physics, and therefore less suited to mathematical modeling, is a misconception. I…
Freedom Preetham
Aug 2
Could Muons Be the Unseen Architects of Biological Evolution?
Could Muons Be the Unseen Architects of Biological Evolution?
Freedom Preetham
Jul 26
Why Do Biologists Find It Hard to Embrace Abstract Mathematical Thinking?
Why Do Biologists Find It Hard to Embrace Abstract Mathematical Thinking?
In the realms of science, two disciplines — biology and physics — stand in stark contrast regarding their foundational principles and…
Freedom Preetham
Jul 25
Part 2: Biological Operators ~ Capturing the Effects of Synonymous SNPs Using Genomic Assays
Part 2: Biological Operators ~ Capturing the Effects of Synonymous SNPs Using Genomic Assays
As an example of how to use foundational biological operators as discussed in Part 1, let us consider synonymous SNPs.
Freedom Preetham
Jul 10
Part 1: Biological Operators ~ Genomic-Level Perturbations and Their Downstream Effects
Part 1: Biological Operators ~ Genomic-Level Perturbations and Their Downstream Effects
Freedom Preetham
Jul 10
Understanding the Limitations and Potential of GWAS in Unraveling Disease Pathology
Understanding the Limitations and Potential of GWAS in Unraveling Disease Pathology
Genome-Wide Association Studies (GWAS) have become indispensable tools in genomics, offering significant insights into the genetic…
Freedom Preetham
Jun 21
The Most Complex Machinery Known to Humankind Runs on 0.22 Microjoules of Energy Every Day
The Most Complex Machinery Known to Humankind Runs on 0.22 Microjoules of Energy Every Day
A cell is incredibly complex, often described as the most sophisticated system known to humankind. This complexity stems from a convergence…
Freedom Preetham
Jun 17
Modeling the Unimaginable Complexity of Gene Regulatory Networks
Modeling the Unimaginable Complexity of Gene Regulatory Networks
In the realm of biological research, the complexity of gene regulatory networks (GRNs) presents an enormous challenge. The intricacies of…
Freedom Preetham
May 29
AlphaFold 3: A Leap Forward in Biomolecular Structure Prediction — Opportunities and Limitations
AlphaFold 3: A Leap Forward in Biomolecular Structure Prediction — Opportunities and Limitations
AlphaFold 3 (AF3) represents a monumental stride in the domain of protein structure prediction, establishing new paradigms in accuracy and…
Freedom Preetham
May 8
The Cross Species Universality of Biological Cells
The Cross Species Universality of Biological Cells
I find myself utterly captivated, deeply fascinated, and wholly consumed by the biological architecture of cells. I spend every waking hour…
Freedom Preetham
May 7
Generative Biology and In-Silico Simulations are the Future of Biology.
Generative Biology and In-Silico Simulations are the Future of Biology.
As traditional wet-lab methodologies begin to exhibit diminishing returns, the future of biological innovation is increasingly being…
Freedom Preetham
May 6
Navigating the Complex Terrain of Biotech Research
Navigating the Complex Terrain of Biotech Research
Statistical Integrity and Data Ethics for PhD Researchers
Freedom Preetham
Apr 30
Advancing Precision in Biomedical Research through Primary-Cell, In-Silico Assays.
Advancing Precision in Biomedical Research through Primary-Cell, In-Silico Assays.
The fusion of artificial intelligence (AI) with cellular biology through in-silico simulations represents a groundbreaking advance in…
Freedom Preetham
Apr 26
The True Cost of Drug Development for Complex Diseases
The True Cost of Drug Development for Complex Diseases
Insights the Media Often Overlooks
Freedom Preetham
Apr 26
Advancements in Cancer Therapies
Advancements in Cancer Therapies
A Pre-Clinical Perspective
Freedom Preetham
Apr 25
The Roles and Implications of Key Gene Types in Oncogenesis
The Roles and Implications of Key Gene Types in Oncogenesis
Cancer remains one of the most challenging diseases to understand and treat, largely due to its complex genetic underpinnings. As our…
Freedom Preetham
Apr 19
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