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Meta Multiomics
Deciphering the Language of Life
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Exploring the Challenges of Protein-Ligand Binding Predictions in AI Through Leash Bio’s BELKA…
Exploring the Challenges of Protein-Ligand Binding Predictions in AI Through Leash Bio’s BELKA…
I’ve been following developments in the field of protein-binding affinity for some time (even though my focus is Genomics), driven by a…
Freedom Preetham
Aug 15
Why Biology Needs Physics and Mathematics
Why Biology Needs Physics and Mathematics
The idea that biology is fundamentally separate from physics, and therefore less suited to mathematical modeling, is a misconception. I…
Freedom Preetham
Aug 2
Could Muons Be the Unseen Architects of Biological Evolution?
Could Muons Be the Unseen Architects of Biological Evolution?
Freedom Preetham
Jul 26
Why Do Biologists Find It Hard to Embrace Abstract Mathematical Thinking?
Why Do Biologists Find It Hard to Embrace Abstract Mathematical Thinking?
In the realms of science, two disciplines — biology and physics — stand in stark contrast regarding their foundational principles and…
Freedom Preetham
Jul 25
Part 2: Biological Operators ~ Capturing the Effects of Synonymous SNPs Using Genomic Assays
Part 2: Biological Operators ~ Capturing the Effects of Synonymous SNPs Using Genomic Assays
As an example of how to use foundational biological operators as discussed in Part 1, let us consider synonymous SNPs.
Freedom Preetham
Jul 10
Part 1: Biological Operators ~ Genomic-Level Perturbations and Their Downstream Effects
Part 1: Biological Operators ~ Genomic-Level Perturbations and Their Downstream Effects
Freedom Preetham
Jul 10
Understanding the Limitations and Potential of GWAS in Unraveling Disease Pathology
Understanding the Limitations and Potential of GWAS in Unraveling Disease Pathology
Genome-Wide Association Studies (GWAS) have become indispensable tools in genomics, offering significant insights into the genetic…
Freedom Preetham
Jun 21
The Most Complex Machinery Known to Humankind Runs on 0.22 Microjoules of Energy Every Day
The Most Complex Machinery Known to Humankind Runs on 0.22 Microjoules of Energy Every Day
A cell is incredibly complex, often described as the most sophisticated system known to humankind. This complexity stems from a convergence…
Freedom Preetham
Jun 17
Modeling the Unimaginable Complexity of Gene Regulatory Networks
Modeling the Unimaginable Complexity of Gene Regulatory Networks
In the realm of biological research, the complexity of gene regulatory networks (GRNs) presents an enormous challenge. The intricacies of…
Freedom Preetham
May 29
AlphaFold 3: A Leap Forward in Biomolecular Structure Prediction — Opportunities and Limitations
AlphaFold 3: A Leap Forward in Biomolecular Structure Prediction — Opportunities and Limitations
AlphaFold 3 (AF3) represents a monumental stride in the domain of protein structure prediction, establishing new paradigms in accuracy and…
Freedom Preetham
May 8
The Cross Species Universality of Biological Cells
The Cross Species Universality of Biological Cells
I find myself utterly captivated, deeply fascinated, and wholly consumed by the biological architecture of cells. I spend every waking hour…
Freedom Preetham
May 7
Generative Biology and In-Silico Simulations are the Future of Biology.
Generative Biology and In-Silico Simulations are the Future of Biology.
As traditional wet-lab methodologies begin to exhibit diminishing returns, the future of biological innovation is increasingly being…
Freedom Preetham
May 6
Navigating the Complex Terrain of Biotech Research: Statistical Integrity and Data Ethics for PhD…
Navigating the Complex Terrain of Biotech Research: Statistical Integrity and Data Ethics for PhD…
Biotechnology research stands at the precipice of scientific progress, revolutionizing healthcare, agriculture, and environmental science…
Freedom Preetham
Apr 30
Advancing Precision in Biomedical Research through Primary-Cell, In-Silico Assays.
Advancing Precision in Biomedical Research through Primary-Cell, In-Silico Assays.
The fusion of artificial intelligence (AI) with cellular biology through in-silico simulations represents a groundbreaking advance in…
Freedom Preetham
Apr 26
The True Cost of Drug Development for Complex Diseases: Insights the Media Often Overlooks
The True Cost of Drug Development for Complex Diseases: Insights the Media Often Overlooks
Developing new therapies for complex diseases such as cancer involves navigating a particularly intricate and resource-intensive pathway…
Freedom Preetham
Apr 26
Advancements in Cancer Therapies: A Pre-Clinical Perspective
Advancements in Cancer Therapies: A Pre-Clinical Perspective
Cancer continues to be one of the leading causes of morbidity and mortality worldwide, driving the ongoing search for more effective and…
Freedom Preetham
Apr 25
Cancer Genomics: The Roles and Implications of Key Gene Types in Oncogenesis
Cancer Genomics: The Roles and Implications of Key Gene Types in Oncogenesis
Cancer remains one of the most challenging diseases to understand and treat, largely due to its complex genetic underpinnings. As our…
Freedom Preetham
Apr 19
A Multidimensional Dissection of Carcinogenesis
A Multidimensional Dissection of Carcinogenesis
Cancer, a quintessential paradigm of pathological complexity, manifests as a consequence of multifactorial interactions that perturb the…
Freedom Preetham
Mar 5
Deciphering the Multifaceted Etiology of Cancer
Deciphering the Multifaceted Etiology of Cancer
The etiological complexity of cancer, characterized by its multifactorial genesis and progression, presents a significant challenge to the…
Freedom Preetham
Feb 8
The Advanced Landscape of Cognit’s LGM Platform
The Advanced Landscape of Cognit’s LGM Platform
Cognit’s Large Genomic Model (LGM) emerges as a formidable player in the functional genomics arena, providing a platform that not only…
Freedom Preetham
Jan 30
Mapping Cellular Dynamics: The Revolution of Cognit’s Genomic Simulations
Mapping Cellular Dynamics: The Revolution of Cognit’s Genomic Simulations
In the domain of functional genomics, the intricate interplay of gene regulatory networks (GRNs) underpins the complexities of biological…
Freedom Preetham
Jan 22
Decoding Longevity by Integrating Advanced Bioassays into Ageing Genomics
Decoding Longevity by Integrating Advanced Bioassays into Ageing Genomics
Longevity refers to the extension of an organism’s lifespan, encompassing not just the duration but also the quality of life. This…
Freedom Preetham
Jan 8
Complexities of Allelic Expression in the Human Genome
Complexities of Allelic Expression in the Human Genome
The study of allelic expression in heterozygous loci of the human genome is a central theme in understanding the intricacies of human…
Freedom Preetham
Nov 30, 2023
The PanGenomic BioGrid Oracle: Innovation at the Heart of Cognit’s LGM
The PanGenomic BioGrid Oracle: Innovation at the Heart of Cognit’s LGM
What does Cognit do?
Freedom Preetham
Nov 15, 2023
Comparing existing DNA LLMs to Cognit’s LGM: Mathematical Highlights
Comparing existing DNA LLMs to Cognit’s LGM: Mathematical Highlights
In the rapidly evolving field of genomics, particularly in oncogenomics, the comparison between DNA Large Language Models (LLMs) like Hyena…
Freedom Preetham
Nov 14, 2023
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