Lab-grown brain organoids mimic the development of the real thing
Researchers have found that stem cell-derived brain organoids 20 months ago have matured like a newborn’s brain
We continue to see futuristic technology being employed in the Healthcare field to find innovative solutions to medical problems. Late last year, I reported on how scientists used a novel technique that will enhance the production of medical parts. This is on top of the 3D printing of Living Skin, Mini-Livers, and biomimetic tongue that we saw over the last little while.
Researchers from the Stanford University and the University of California, Los Angeles (UCLA) have now made a breakthrough discovery in the three-dimensional human stem cell-derived brain organoids that they developed over 20 months ago. The lab-grown organoids were seen to mature in a similar fashion to that of human brain development.
According to the research, 3D organoids follow an internal clock that guides their maturation in sync with the timeline of human development. Neurobiologist Sergiu Pașca has been making & studying brain organoids for about 10 years and over the period his team has learned that these tissue blobs can thrive for years. In the latest study, his team collaborated with the researchers at UCLA to analyze how the blobs changed over their life spans.
The process of creating human brain organoids starts off with induced pluripotent stem cells (also known as iPS cells), which are treated with specific chemicals that cause them to mature into different types of brain cells. Derived from skin or blood cells, they are reprogrammed back to an embryonic stem cell-like state — enabling scientists to create any cell type.
“… these 3D brain organoids follow an internal clock, which progresses in a lab environment in parallel to what occurs inside a living organism… they reach post-natal maturity around 280 days in culture & after that begin to model aspects of the infant brain, including known physiological changes in…